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A New Strategy for Solid-Phase Depsipeptide Synthesis Using Recoverable Building Blocks

✍ Scribed by Albericio, Fernando; Burger, Klaus; Ruíz-Rodríguez, Javier; Spengler, Jan


Book ID
115440649
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
215 KB
Volume
7
Category
Article
ISSN
1523-7060

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A New Strategy for Solid-Phase Synthesis
✍ Dipl.-Chem. Tim Bielfeldt; Dipl.-Chem. Stefan Peters; Dr. Morten Meldal; Prof. D 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB 👁 2 views

with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target