A systematic study of nucleophilic displacement of mesyl groups using benzylamine was carried out on Multipin Synphaseβ’ supports. The optimal conditions were applied for the combinatorial synthesis of polyamine derivatives from commercially available aminoalcohols and amines.
β¦ LIBER β¦
Solid-Phase Polyamine Synthesis Using Piperazine and Piperidine Building Blocks
β Scribed by Olsen, Christian A.; Witt, Matthias; Jaroszewski, Jerzy W.; Franzyk, Henrik
- Book ID
- 118235280
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 66 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1523-7060
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Different protective groups for (5R)-5-hydroxy-l-lysine were investigated in silver silicate promoted glycosylations with acetobromogalactose as glycosyl donor. Best results were obtained with Fmoc-Hyl(Cbz)-OAll, which was glycosylated in 80% yield. Removal of the allyl group gave a b-d-galactosylat