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A new selective type of aromatic substitution: homolytic amidation

✍ Scribed by F. Minisci; G.P. Gardini; R. Galli; F. Bertini

Publisher
Elsevier Science
Year
1970
Tongue
French
Weight
119 KB
Volume
11
Category
Article
ISSN
0040-4039

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✦ Synopsis

The prevalent nucleophilic character of the alkyl radicals' readily permits thehomolyticalkylation of protonated heteroaromatic bases2, due to the contribution of polar forms in the transition state:

The oxygen atom of ethersand alcohols as well as the nitrogen of amides and amines, attached to the carbon radical, increase the final nucleophilic character of reactive species through their contribution to the stabilization of the cation R+ and make still easier the homolytic alkylation:

πŸ“œ SIMILAR VOLUMES

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