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A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia

✍ Scribed by Chapiro, E; Russell, L J; Struski, S; Cavé, H; Radford-Weiss, I; Valle, V D; Lachenaud, J; Brousset, P; Bernard, O A; Harrison, C J

Book ID: 109887425
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 450 KB
Volume: 24
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2010.93

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## Abstract Chromosomal translocations involving the immunoglobulin heavy chain (__IGH__) locus are common abnormalities in mature B‐cell neoplasms. Recent findings have also revealed their significant role in B‐cell precursor acute lymphoblastic leukemia. As a rule, __IGH__ translocations generate