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A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

✍ Scribed by Bernard, O A; Busson-LeConiat, M; Ballerini, P; Mauchauffé, M; Della Valle, V; Monni, R; Khac, F Nguyen; Mercher, T; Penard-Lacronique, V; Pasturaud, P


Book ID
110055009
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
442 KB
Volume
15
Category
Article
ISSN
0887-6924

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Activation of HOX11L2 by juxtaposition w
✍ Roderick A.F. MacLeod; Stefan Nagel; Maren Kaufmann; Johannes W.G. Janssen; Hans 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

Cytogenetic analysis of a pediatric T-cell acute lymphoblastic leukemia (ALL) cell line (HPB-ALL) revealed the cryptic t(5;14)(q35;q32.2), recently found in 15-20% pediatric T-ALL patients, with 5q35 and 14q32.2 breakpoints at 5'-HOX11L2 and 3'-BCL11B, respectively. Expression of both BCL11B, which