MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia

✍ Scribed by Elisa Tassano; Maura Acquila; Elisa Tavella; Concetta Micalizzi; Claudio Panarello; Cristina Morerio

• Book ID: 102843301
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 858 KB
• Volume: 49
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.20776

✦ Synopsis

Abstract

Chromosomal translocations involving the immunoglobulin heavy chain (IGH) locus are common abnormalities in mature B‐cell neoplasms. Recent findings have also revealed their significant role in B‐cell precursor acute lymphoblastic leukemia. As a rule, IGH translocations generate transcriptional activation of the oncogene localized in the proximity of the breakpoint. In this study, we describe a pediatric case of B‐cell precursor acute lymphoblastic leukemia showing microRNA‐125b‐1 (MIR125B1) and BLID gene overexpression, resulting from a novel t(11;14)(q24.1;q32) translocation involving IGH. This is the first report describing the upregulation of a microRNA due to its juxtaposition to protein‐coding gene regulatory elements and the overexpression of two neighboring genes as a consequence of transcriptional enhancers localized in the vicinity of the IGH gene. © 2010 Wiley‐Liss, Inc.