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A new rapid, regiospecific synthesis of 15-(p-[123I]iodophenyl)pentadecanoic acid

✍ Scribed by M. M. Goodman; F. F. Knapp; P. Richards; F. Mausner


Book ID
112686111
Publisher
Springer
Year
1985
Tongue
English
Weight
435 KB
Volume
89
Category
Article
ISSN
1588-2780

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High specific activity 15-p-[123I]iodoph
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An improved labeling procedure for 15-(p-[123I]iodophenyl)pentadecanoic acid (IPPA) is reported. The exchange labeling yield was greater than 95%. The radiochemical yield is influenced by the presence of sodium. The major advantage of this method is that very high specific activity i.e. upto 190 mCi

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The uptake and turnover of omega(p 123I iodophenyl-)pentadecanoic acid (I-PPA), a radioiodinated free-fatty-acid analog, was examined in the heart, lung, liver, kidneys, spleen, and skeletal muscle of rats. At 2 min post injection, a high cardiac uptake of 4.4% dose per gram had already been achieve

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15-(p-Iodophenyl) pentadecanoic acid labelled with carbon-14 in the carboxyl group is obtained with good yields in five steps from [14C]NaCN, starting from 14-bromo 1-phenyl tetradecane 2. Specific radioactivity: 0.019 mCi/mg, 8.45 mCi/mmol; radiochemical yield: 74.6%.