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Efficient production of 15-(para-[123I]iodophenyl) pentadecanoic acid

✍ Scribed by Hayes Dougan; Donald M. Lyster; John S. Vincent


Book ID
103919817
Publisher
Elsevier Science
Year
1986
Weight
201 KB
Volume
37
Category
Article
ISSN
0883-2889

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High specific activity 15-p-[123I]iodoph
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An improved labeling procedure for 15-(p-[123I]iodophenyl)pentadecanoic acid (IPPA) is reported. The exchange labeling yield was greater than 95%. The radiochemical yield is influenced by the presence of sodium. The major advantage of this method is that very high specific activity i.e. upto 190 mCi

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The uptake and turnover of omega(p 123I iodophenyl-)pentadecanoic acid (I-PPA), a radioiodinated free-fatty-acid analog, was examined in the heart, lung, liver, kidneys, spleen, and skeletal muscle of rats. At 2 min post injection, a high cardiac uptake of 4.4% dose per gram had already been achieve