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Synthesis of 15-(p-iodophenyl) pentadecanoic acid labelled with carbon-14

✍ Scribed by D. Le Bars; C. Luu-Duc; P.M. Leo; M. Apparu; M. Vidal; M. Comet

Book ID
103919708
Publisher
Elsevier Science
Year
1986
Weight
192 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

15-(p-Iodophenyl) pentadecanoic acid labelled with carbon-14 in the carboxyl group is obtained with good yields in five steps from [14C]NaCN, starting from 14-bromo 1-phenyl tetradecane 2. Specific radioactivity: 0.019 mCi/mg, 8.45 mCi/mmol; radiochemical yield: 74.6%.

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with good yield in t w o steps f r o m Na14CN, starting from 14-methyl 1-phenyl-tetradecanol methanesulfonate with a specific radioactivity : 108.25 pCi/mg, 1.92 mCilmmo1. and in a radiochemical yield of 50% of the theoretical amount. p-Methyl-15-phenyl-pentadecanoic acid labelled with carbon-14 wa