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A New Locus for Autosomal Recessive Hereditary Spastic Paraplegia Maps to Chromosome 16q24.3

✍ Scribed by Giuseppe De Michele; Maurizio De Fusco; Francesca Cavalcanti; Alessandro Filla; Roberto Marconi; Giampiero Volpe; Antonella Monticelli; Andrea Ballabio; Giorgio Casari; Sergio Cocozza


Book ID
117852476
Publisher
American Society of Human Genetics
Year
1998
Tongue
English
Weight
88 KB
Volume
63
Category
Article
ISSN
0002-9297

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✍ Inge A. Meijer; Patrick Cossette; Julie Roussel; Melanie Benard; Sylvie Toupin; πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 218 KB πŸ‘ 1 views

## Abstract The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lower‐limb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q

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Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. W