A New Locus for Autosomal Recessive Hereditary Spastic Paraplegia Maps to Chromosome 16q24.3
β Scribed by Giuseppe De Michele; Maurizio De Fusco; Francesca Cavalcanti; Alessandro Filla; Roberto Marconi; Giampiero Volpe; Antonella Monticelli; Andrea Ballabio; Giorgio Casari; Sergio Cocozza
- Book ID
- 117852476
- Publisher
- American Society of Human Genetics
- Year
- 1998
- Tongue
- English
- Weight
- 88 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/301930
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## Abstract The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lowerβlimb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q
Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. W