## Abstract The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lowerβlimb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q
A locus for complicated hereditary spastic paraplegia maps to chromosome 1q24-q32
β Scribed by Sergiu C. Blumen; Simon Bevan; Saif Abu-Mouch; David Negus; Michael Kahana; Rifka Inzelberg; Aziz Mazarib; Ahmad Mahamid; Ralph L. Carasso; Hanoch Slor; David Withers; Puiu Nisipeanu; Ruth Navon; Evan Reid
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 388 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0364-5134
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Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. W
## Abstract Hereditary hemorrhagic telangiectasia (HHT) is a genetically and clinically heterogeneous multisystem vascular dysplasia. Mutations of the endoglin and __ACVRL1__ genes are known to cause HHT. However, existence of HHT families in which linkage to these genes has been excluded has sugge