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New locus for hereditary spastic paraplegia maps to chromosome 1p31.1-1p21.1

✍ Scribed by Antonio Orlacchio; Toshitaka Kawarai; Fabrizio Gaudiello; Peter H. St George-Hyslop; Roberto Floris; Giorgio Bernardi


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
230 KB
Volume
58
Category
Article
ISSN
0364-5134

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A novel locus for pure recessive heredit
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## Abstract The hereditary spastic paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by progressive lower‐limb spasticity. In this study, we performed linkage analysis on an autosomal recessive pure HSP family and mapped the disease to chromosome 10q

Novel locus for autosomal dominant pure
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Hereditary spastic paraplegia is a clinically and genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. Seven loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have already been mapped on chromosomes 14q, 2p, 15q, 8p, 12q, 19q, and 2q. W

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## Abstract We performed genomewide linkage analysis of a Japanese family with autosomal dominant parkinsonism, which exhibits clinical features compatible with those of common Parkinson's disease. Parametric two‐point linkage analysis yielded a highest log odds (LOD) score of 4.32 at D12S345 (12p1