A New Highly Selective Metabotropic Excitatory Amino Acid Agonist: 2-Amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric Acid
✍ Scribed by Bräuner-Osborne, Hans; Sløk, Frank A.; Skjærbæk, Niels; Ebert, Bjarke; Sekiyama, Naohiro; Nakanishi, Shigetada; Krogsgaard-Larsen, Povl
- Book ID
- 120975998
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 310 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo
## Abstract The excitatory, amino acid ±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.