𝔖 Bobbio Scriptorium
✦   LIBER   ✦

ChemInform Abstract: A New Highly Selective Metabotropic Excitatory Amino Acid Agonist: 2- Amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric Acid.

✍ Scribed by H. BRAEUNER-OSBORNE; F. A. SLOEK; N. SKJAERBAEK; B. EBERT; N. SEKIYAMA; S. NAKANISHI; P. KROGSGAARD-LARSEN


Book ID
112040738
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of tritiated (RS)-2-amino-2-(3
✍ Tommy N. Johansen; Venkataraman Balasubramanian; Ulf Madsen; John W. Ferkany; Po 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 329 KB 👁 2 views

RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo

An expedient synthesis of (±)-2-amino-3-
✍ Robert N. Hanson; Farid A. Mohamed 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 277 KB

## Abstract The excitatory, amino acid ±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.