ChemInform Abstract: A New Highly Selective Metabotropic Excitatory Amino Acid Agonist: 2- Amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric Acid.
✍ Scribed by H. BRAEUNER-OSBORNE; F. A. SLOEK; N. SKJAERBAEK; B. EBERT; N. SEKIYAMA; S. NAKANISHI; P. KROGSGAARD-LARSEN
- Book ID
- 112040738
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 34 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
RS)-2-Amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA) is a potent and selective agonist at the NMDA subgroup of excitatory amino acid receptors. To probe its interaction with these receptors we have developed a synthesis of [3H]AMAA. Bromination of a protected form of AMAA with NBS follo
## Abstract The excitatory, amino acid ±2‐amino‐3‐(3‐hydroxy‐5‐methylisoxazol‐4‐yl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2‐ynoate. The key step was the facile preparation of methyl 3‐bromo‐5‐methylisoxazole‐4‐carboxylate.