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A New and Efficient Solid Phase Synthesis of Hydroxamic Acids

✍ Scribed by Ngu, Khehyong; Patel, Dinesh V.

Book ID
121309712
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
63 KB
Volume
62
Category
Article
ISSN
0022-3263

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A novel linkage for the solid-phase synthesis of hydroxamic acids is described. The linkage is stable to all reagents commonly used in Fmoc peptide synthsis. Cleavage is induced by treatment with trifluoroacetie acid, providing hydroxamic acids in high purity and good yields.