A series of spiro-isoxazolines la-e was prepared in an one-step procedure by treating the corresponding tricarbonyl 3a-e derivatives with hydroxylamine hydrochloride.
A New Access to Dispiro 7-Oxaindazolidines Spiroxindole Derivatives.
✍ Scribed by Rathna Durga R. S. Manian; Jayadevan Jayashankaran; Raghavachary Raghunathan
- Book ID
- 101959951
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 94 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## 1999 isoxazole derivatives isoxazole derivatives R 0240 ## 16 -135 A New Access to Spiro-isoxazolines Derivatives. -A new one-step procedure is presented for the synthesis of title compounds by treating the corresponding tricarbonyl substrates [cf. (IV) and (VI)] with hydroxylamine hydrochlor
## Abstract 1,4‐Disubstituted thiosemicarbazides **1b–f** reacted with ethenetetracarbonitrile (**5**) in di‐ methylformamide with formation of 2‐substituted 5‐phenyl‐1,3,4‐thiadiazoles **2a–f** and 2‐substituted 5‐phenyl‐1,3,4‐oxadiazoles **4a–f**. Upon addition of **5** to **1c–e** in chlorobenze