N-tosyl amides and lactams can be prepared easily and under mild conditions by the inter-or intramolecular condensation of carboxylic acids and secondary sulfonamides. The coupling reagent used is dicyclohaxylcarbodiimide (DCC) in the presence of 4-pyrrolidioopyridine (4-PPY) and the reactions proce
A mild two-step method for the hydrolysis of lactams and secondary amides
โ Scribed by Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A.
- Book ID
- 111674122
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 401 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Mild Method for the Synthesis of Thiazolines from Secondary and Tertiary Amides. -Base-promoted treatment of amides [cf. (I)] with triflic anhydride generates an iminium or imino triflate which reacts with an aminothiol directly to biologically interesting thiazolines. When optically pure cysteine
1998 amide formation, amide hydrolysis amide formation, amide hydrolysis O 0320 23 -069 A New Mild Method for the Cleavage of the Amide Bond: Conversion of Secondary and Tertiary Amides to Esters. -A variety of secondary and tertiary amides (I) (21 examples) is efficiently converted to the correspon