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A mild method for the alcoholysis of β-lactams

✍ Scribed by Claudio Palomo; Jesus M. Aizpurua; Carmen Cuevas; Antonia Mielgo; Regina Galarza


Book ID
103411132
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
240 KB
Volume
36
Category
Article
ISSN
0040-4039

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A mild and efficient method for the prep
✍ David Tanner; Peter Somfai 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 277 KB

N-tosyl amides and lactams can be prepared easily and under mild conditions by the inter-or intramolecular condensation of carboxylic acids and secondary sulfonamides. The coupling reagent used is dicyclohaxylcarbodiimide (DCC) in the presence of 4-pyrrolidioopyridine (4-PPY) and the reactions proce