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A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia

✍ Scribed by John Panetta; Yuri Yanishevski; Ching-Hon Pui; John T. Sandlund; Jeffrey Rubnitz; Gaston K. Rivera; Raul Ribeiro; William E. Evans; Mary V. Relling

Book ID
105991690
Publisher
Springer
Year
2002
Tongue
English
Weight
347 KB
Volume
50
Category
Article
ISSN
0344-5704

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Methotrexate infusions in poor prognosis acute lymphoblastic leukemia: II. High-dose methotrexate (HDM) in acute lymphoblastic leukemia in childhood: A pilot study from April 1981
✍ Moe, Peter Johan ;Wesenberg, Finn ;Kolmannskog, Svein πŸ“‚ Article πŸ“… 1986 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

The pilot study using HDM in all cases of ALL in childhood had been run for 4 112 years as of September 1985. Fourteen (23%) of all 62 diagnosed cases of ALL had WBC above 50 x 109/L, all 14 achieved CR. Three of them were below one year of age, two also had WBC above 400 x 109/L, the third infant h