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A Rare Complication of Intrathecal Methotrexate in a Child with Acute Lymphoblastic Leukemia

✍ Scribed by Tufekci, Ozlem; Yilmaz, Sebnem; Karapinar, Tuba Hilkay; Gozmen, Salih; Cakmakci, Handan; Hiz, Semra; Irken, Gulersu; Oren, Hale

Book ID
125811965
Publisher
Informa plc
Year
2011
Tongue
English
Weight
196 KB
Volume
28
Category
Article
ISSN
0888-0018

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Acute fatal myeloencephalopathy after co
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia
✍ von der Weid, Nicholas X. ;de Crousaz, Henriette ;Beck, Daniel ;Deonna, Thierry πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 806 KB

We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support