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Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia

✍ Scribed by von der Weid, Nicholas X. ;de Crousaz, Henriette ;Beck, Daniel ;Deonna, Thierry ;Miklossy, J. ;Janzer, R. C.

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 806 KB
Volume: 19
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950190309

No coin nor oath required. For personal study only.

✦ Synopsis

We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.

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