Methotrexate pharmacokinetics in infants with acute lymphoblastic leukemia
β Scribed by Patrick A. Thompson; Daryl J. Murry; Gary L. Rosner; Simon Lunagomez; Susan M. Blaney; Stacey L. Berg; Bruce M. Camitta; ZoAnn E. Dreyer; Lisa R. Bomgaars
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 279 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
## Abstract A retrospective pharmacokinetic analysis was done of methotrexate serum levels after highβdose treatment (HDβMTX, four cycles at twoβweek intervals of 5 g/sq.^1^m. over 24 h i.v.) in children with nonβB acute lymphoblastic leukemia (ALL) with the specific aim of seeking differences in p
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (