A limited sampling strategy to estimate individual pharmacokinetic parameters of methotrexate in children with acute lymphoblastic leukemia
✍ Scribed by Christine Piard; Françoise Bressolle; May Fakhoury; Daolun Zhang; Karina Yacouben; André Rieutord; Evelyne Jacqz-Aigrain
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 527 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0344-5704
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📜 SIMILAR VOLUMES
We studied the disposition phannacokinetics of methotrexate (MTX) given orally to 16 children with acute lyrnphoblastic leukemia (ALL) and its relation to the pharrnacokinetics of 6-mercaptopurine (6MP) in the same children. There was an eightfold variability in area-under-concentration tirnecurve (
Methotrexate (MTX) infusions of 500-1,000 mg/m2 over 24 hours may improve survival and prevent relapse in children with acute lymphoblastic leukemia (ALL). Childrens Cancer Group (CCG) Study 139 compared weekly oral methotrexate 20 mg/m2/ week (oral MTX) to MTX 500 mg/m2 infused over 24 hours (IV MT
## Abstract Concentrations of __7__‐hydroxy‐methotrexate (__7__‐OH‐MTX) were determined in serum samples obtained after 266 infusions of methotrexate administered to 58 children with acute lymphoblastic leukemia. The dose of methotrexate (MTX) was in the range of 0.5‐33.6 g/m^2^. Pharmacokinetic pa