A High-Level Expression of CYP2A in the Lung of the Suncus (Suncus murinus) and Its Role in the Activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
β Scribed by Taisei Mushiroda; Noritaka Ariyoshi; Kanzo Kimura; Eiji Takahara; Osamu Nagata; Hideo Kato; Tetsuya Kamataki
- Book ID
- 115585404
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 77 KB
- Volume
- 269
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
The carcinogenic tobacco-specif ic nitrosamines 4- (methylnitrosemino) -1-(3-pyridyl) -1-butanone (NNK) and N'-nitrosonornicotine (NNN), as well as the model compound 4-(carbethoxynitrosamino) -1-(3-pyridyl) -1butanone, were synthesized with tritium at the 5-position of the pyridine ring. In each c
## Abstract Urinary metabolites of the tobaccoβspecific nitrosamine 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanone (NNK), 4β(methylnitrosamino)β1β(3βpyridyl)β1βbutanol (NNAL) and its glucuronides, termed total NNAL, have recently been shown to be good predictors of lung cancer risk, years before di