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A general synthesis of side chain derivatives of Δ9-thc

✍ Scribed by Colin G. Pitt; Herbert H. Seltzman; Yousry Sayed; Charles E. Twine Jr.; David L. Williams

Publisher
Elsevier Science
Year
1978
Tongue
French
Weight
214 KB
Volume
19
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of (6aR, lOaR)-trans-3-(1',3'-dithian-2'-yl]-6a,7,8,lOa-tetrahydro-6,6,9trimethyl-6H-dibenzo[b,d]pyran-l-01 t-butyldimethylsilyl ether (4&) is reported. The use of this compound as a source of side chain derivatives of cannabinoids is illustrated by syntheses of l'-,2'-,3'-and 4'-hydroxy-A'-THC, and 3-carboxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-l-o1 (6).

Side chain derivatives of cannabinoids, the biologically active principals of marihuana,

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