✦ LIBER ✦

A comparison of LSD-25 with (−)-Δ9-trans-tetrahydrocannabinol (THC) and attempted cross tolerance between LSD and THC

✍ Scribed by Harris Isbell; D. R. Jasinski

Publisher: Springer
Year: 1969
Tongue: English
Weight: 517 KB
Volume: 14
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00403684

No coin nor oath required. For personal study only.

✦ Synopsis

The objective and subjective effects of 0.5 and 1.5 meg/kg of LSD intramuscularly were compared with those of 75 and 225 mcg/kg of (--)-AP-transtetrahydrocannabinol by smoking in the same eight subjects.
The objective effects of LSD and THC differed markedly. LSD increased body temperature, systolic and diastolic blood pressure, lowered the threshold for the knee-jerk, and dilated the pupils. TttC had none of these effects but caused more marked tachycardia than did LSD.
The subjective effects of the two drugs could not be readily distinguished by the methods used. Both LSD and TItC are psychotomimetic drugs. 4. Patients tolerant to LSD were not cross-tolerant to THC, indicating that the mental effects of the two drugs are probably mediated by different mechanisms.

📜 SIMILAR VOLUMES

Lack of cross-tolerance in rats among (−

Lack of cross-tolerance in rats among (−) Δ9-trans-tetrahydrocannabinol (Δ9-THC), cannabis extract, mescaline and lysergic acid diethylamide (LSD-25)

✍ M. Teresa A. Silva; E. A. Carlini; U. Claussen; F. Korte 📂 Article 📅 1968 🏛 Springer 🌐 English ⚖ 465 KB

Cross tolerance between mescaline and LS

Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions

✍ A. B. Wolbach; Harris Isbell; E. J. Miner 📂 Article 📅 1962 🏛 Springer 🌐 English ⚖ 831 KB

Although some differences have been reported, the reactions produced in man by the diethy!amide of lysergie acid (LSD-25) and mescaline seem very similar. Both drugs cause autonomic stimulation manifested by increased pupillary size, increase in pulse rate and blood pressure, and elevation of body t

Comparison of δ9-THC, LSD-25 and scopola

Comparison of δ9-THC, LSD-25 and scopolamine on non-spatial single alternation performance in the runway

✍ Loren L. Miller; Wm. G. Drew; A. Wikler 📂 Article 📅 1973 🏛 Springer 🌐 English ⚖ 619 KB

Rats were trained in a straight runway on a non-spatial single alternation (NSSA) which involved presentation of reward (R) and nonreward (N) in a fixed repeating sequence (i.e. R--N--R--N...). Patterned running results since rats learned to run fast on R trials and slow on N trials. This task can b