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Synthesis of side chain specifically deuterated (−)-Δ9-tetrahydrocannabinols

✍ Scribed by Spyros P. Nikas; Ganesh A. Thakur; Alexandros Makriyannis

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
111 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

(−)‐Δ^9^‐Tetrahydrocannabinols specifically deuterated at the n‐pentyl side chain were prepared using the corresponding resorcinols as key intermediates. To obtain the deuterated resorcinols we developed conditions under which no deuterium scrambling or loss was observed. The methodology allows for the preparative scale synthesis of deuterated resorcinols and corresponding (−)‐Δ^9^‐tetrahydrocannabinols. Copyright © 2002 John Wiley & Sons, Ltd.

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