## Abstract Site specific deuterated primaquines were prepared. The attempts to prepare these by deuterolysis of bromoprimaquines were unsuccessful because the required bromoprimaquines could not be produced satisfactorily by alkylation of the various bromo‐6‐ methoxy‐8‐aminoquinolines. Instead pri
Synthesis of specifically-deuterated procaine and tetracaine
✍ Scribed by Yvan Boulanger; Leonard C. Leitcht
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- French
- Weight
- 290 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Local anesthetics procaine and tetracaine have been specifically‐deuterated in two and three positions, respectively, for use in deuterium nuclear magnetic resonance experiments. The experimental procedure is either new or an adaptation of early synthetic methods.
📜 SIMILAR VOLUMES
## Abstract Two site specifically deuterated primaquines were prepared. 4′,4′‐Dideutero primaquine **3** was obtained from the corresponding dideutero alcohol which was prepared by the low temperature reduction of the ester compound **4** with lithium aluminium deuteride. 1′‐Deutero primaquine r wa
## Abstract BG9928, a high affinity adenosine A~1~ antagonist, is currently in Phase II clinical trials for the treatment of congestive heart failure. A deuterium‐labeled version of the molecule was synthesized and used as a standard for __in vivo__ pharmacokinetic and __in vitro__ metabolism studi
## Abstract (−)‐Δ^9^‐Tetrahydrocannabinols specifically deuterated at the __n__‐pentyl side chain were prepared using the corresponding resorcinols as key intermediates. To obtain the deuterated resorcinols we developed conditions under which no deuterium scrambling or loss was observed. The method
## Abstract __trans__‐4‐Octene‐1,1,1‐^2^H~3~; −2,2‐^2^H~2~; −3,3‐^2^H~2~ and −4‐^2^H~1~ have been synthesized. The electron impact mass spectra and isotopic enrichment of these compounds have been measured and are reported.