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Synthesis of site specifically deuterated primaquines II. N-alkyl deuterated primaquines

✍ Scribed by James D. McChesney; Srinivasan Sarangan

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 278 KB
Volume: 21
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580210402

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✦ Synopsis

Abstract

Two site specifically deuterated primaquines were prepared. 4′,4′‐Dideutero primaquine 3 was obtained from the corresponding dideutero alcohol which was prepared by the low temperature reduction of the ester compound 4 with lithium aluminium deuteride. 1′‐Deutero primaquine r was prepared by the reductive alkylation of 6‐methoxy‐8‐aminoquinoline with N‐(2‐oxopentyl)‐phthalimide in the presence of sodium cyanoborodeuteride followed by removal of protective phthalimide group.

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