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A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients

✍ Scribed by Mach, Bernard; Reith, Walter; Masternak, Krzysztof; Barras, Emmanuèle; Zufferey, Madeleine; Conrad, Bernard; Corthals, Garry; Aebersold, Ruedi; Sanchez, Jean-Charles; Hochstrasser, Denis F.


Book ID
109734686
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
208 KB
Volume
20
Category
Article
ISSN
1061-4036

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## Communicated by Henrik Dahl MHC class II deficiency is a severe primary immunodeficiency characterised by the absence of major histocompatibility complex class II (MHC-II) gene expression. It is genetically heterogeneous and can result from defects in at least four different trans-acting regula