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Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA

✍ Scribed by Virginia Quan; Michael Towey; Steven Sacks; A.P. Kelly


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
137 KB
Volume
49
Category
Article
ISSN
0093-7711

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The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells. The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-y on a wide variety of cell types. Retinoblastom