In order to develop an effective immunotherapy for hematological malignancies, we investigated the applicability of class II transactivator (CIITA), which had been demonstrated to regulate the expression of MHC class II (MHC-II) by assembling the transcription factors of MHC-II molecules, for immuno
✦ LIBER ✦
The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells
✍ Scribed by Andrea De Lerma Barbaro; Francesco A. Procopio; Lorenzo Mortara; Giovanna Tosi; Roberto S. Accolla
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 242 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0014-2980
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## Abstract In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed. Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of c