RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
β Scribed by Durand, B.
- Book ID
- 111745247
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 700 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0261-4189
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π SIMILAR VOLUMES
## Communicated by Henrik Dahl MHC class II deficiency is a severe primary immunodeficiency characterised by the absence of major histocompatibility complex class II (MHC-II) gene expression. It is genetically heterogeneous and can result from defects in at least four different trans-acting regula
The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells. The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-y on a wide variety of cell types. Retinoblastom