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A Formal Synthesis of (−)-Paroxetine by Enantioselective Ring Enlargement of a Trisubstituted Prolinol

✍ Scribed by Janine Cossy; Olivier Mirguet; Domingo Gomez Pardo; Jean-Roger Desmurs

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
184 KB
Volume
2002
Category
Article
ISSN
1434-193X

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✦ Synopsis

A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. The substituted piperidine ring precursor of (-)-paroxetine was generated by means of a stereoselective ring expansion of prolinol.

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