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ChemInform Abstract: Convenient Formal Synthesis of (.+-.)-Paroxetine.

✍ Scribed by Subhash P. Chavan; Dushant A. Khobragade; Ashok B. Pathak; Uttam R. Kalkote


Publisher
John Wiley and Sons
Year
2008
Weight
24 KB
Volume
39
Category
Article
ISSN
0931-7597

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A Convenient Synthesis of (−)-Paroxetine
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## Abstract A convenient synthesis of the antidepressant paroxetine starting from 1‐benzyl‐4‐piperidone (**2**) is reported. A stereoselective reduction resulted in __cis__‐piperidine‐3‐methanol [(**+**)‐**6**]. The reaction between __cis__‐piperidine‐3‐methanol mesylate (**7**) and sesamol led to