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A Formal Synthesis of (-)-Paroxetine (I) by Enantioselective Ring Enlargement of a Trisubstituted Prolinol.

✍ Scribed by Janine Cossy; Olivier Mirguet; Domingo Gomez Pardo; Jean-Roger Desmurs

Publisher: John Wiley and Sons
Year: 2003
Weight: 59 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200311144

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A Formal Synthesis of (−)-Paroxetine by

A Formal Synthesis of (−)-Paroxetine by Enantioselective Ring Enlargement of a Trisubstituted Prolinol

✍ Janine Cossy; Olivier Mirguet; Domingo Gomez Pardo; Jean-Roger Desmurs 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 184 KB

A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (-)-paroxetine. The substituted piperidine ring precursor of (-)-paroxetine was generated by means of a stereoselective ring expansion of prolinol.

A Ring-Closing Metathesis Approach Towar

A Ring-Closing Metathesis Approach Toward Formal Total Synthesis of (+)-Diplodialide A (I).

✍ R. Vijaya Anand; S. Baktharaman; Vinod K. Singh 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 55 KB

A Direct Retro-Reformatsky Fragmentation

A Direct Retro-Reformatsky Fragmentation: Formal Ring Enlargement of Cyclic Ketones for Novel and Practical Synthesis of Heterocyclic Enamines.

✍ Mei-Xin Zhao; Mei-Xiang Wang; Chu-Yi Yu; Zhi-Tang Huang; George W. J. Fleet 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 164 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

A Formal Asymmetric Synthesis of (+)-Ana

A Formal Asymmetric Synthesis of (+)-Anatoxin-a Using an Enantioselective Deprotonation Strategy on an Eight-Membered Ring

✍ Varinder K. Aggarwal; Paul S. Humphries; Ashley Fenwick 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 1 views

A New Synthesis of Ring-Fused Alkylidene

A New Synthesis of Ring-Fused Alkylidenecyclobutanes by Ring-Enlargement Reaction of Bicyclo[n.1.0]alkylidene Derivatives.

✍ Morshed Alam Chowdhury; Hisanori Senboku; Masao Tokuda 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 91 KB 👁 1 views

A new synthesis of ring-fused alkylidene

A new synthesis of ring-fused alkylidenecyclobutanes by ring-enlargement reaction of bicyclo[n.1.0]alkylidene derivatives

✍ Morshed Alam Chowdhury; Hisanori Senboku; Masao Tokuda 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 98 KB

Bicyclo[n.1.0]alkylidene derivatives (ring-fused alkylidenecyclopropanes) reacted with diazomethane to give spiro-pyrazolines regioselectively. Thermal decomposition of spiro-pyrazolines resulted in ring-enlargement and afforded ring-fused alkylidenecyclobutanes (bicyclo[n.2.0]alkylidene derivatives