𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A facile synthesis of tetrasubstituted 2,3-dihydrofuran derivatives using poly(ethylene glycol) as soluble support

✍ Scribed by Chun Feng; Cuifen Lu; Zuxing Chen; Nianguo Dong; Jiawei Shi; Guichun Yang

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
247 KB
Volume
47
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

magnified image

A facile synthesis of tetrasubstitude 2,3‐dihydrofurans has been conducted using poly(ethylene glycol) (PEG) as a soluble polymer support. The PEG‐supported pyridinium ylides react with 3‐arylidene‐2,4‐pentanedione in the presence of triethylamine (TEA) via conjugate addition to form PEG‐supported dihydrofuran derivatives, being cleaved by 1% KCN/EtOH to afford trans‐tetrasubstitude‐2,3‐dihydrofurans, varying from good to excellent yields. J. Heterocyclic Chem., (2010).

📜 SIMILAR VOLUMES

Synthesis of a library of 1,2,3,7-tetras
Synthesis of a library of 1,2,3,7-tetrasubstituted indolizines using poly(ethylene glycol) as soluble support
✍ Guizhou Yue; Zuxing Chen; Guichun Yang 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 386 KB

## Abstract magnified image A library of 1,2,3,7‐tetrasubstituted indolizines has been synthesized using poly(ethylene glycol) (PEG) as soluble polymer support. The PEG‐bound pyridinium salts reacted with alkenes or alkynes in the presence of Et~3~N __via__ 1,3‐dipolar cycloaddition to give PEG‐bo

Traceless synthesis of quinazoline-2,4-d
Traceless synthesis of quinazoline-2,4-diones by curtius rearrangement reaction using poly(ethylene glycol) as soluble polymeric support
✍ Yanling Huang; Cuifen Lu; Zuxing Chen; Guichun Yang 📂 Article 📅 2007 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 272 KB

## Abstract magnified image We have developed an efficient method to synthesize various quinazoline‐2,4‐diones using poly‐(ethylene glycol) as soluble polymeric support. The procedure of this reaction included: formation of acyl azide, efficient Curtius rearrangement, nucleophlic addition with ami

Soluble poly(ethylene glycol) supported
Soluble poly(ethylene glycol) supported efficient synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
✍ Zheng Li; Jingya Yang; Junke Wang; Xicun Wang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 112 KB

## Abstract An efficient soluble poly(ethylene glycol) (PEG) supported liquid‐phase parallel synthetic method for 2,5‐disubstituted 1,3,4‐oxadiazoles and 1,3,4‐thiadiazoles is described. 2‐Aryl‐5‐(4′‐methoxycarbonylphenoxymethyl)‐1,3,4‐oxadiazoles and 2‐aryloxymethyl‐5‐(4′‐methoxycarbonylphenoxyace

Poly(ethylene glycol)-Supported 4-Alkylt
Poly(ethylene glycol)-Supported 4-Alkylthio-Substituted Aniline − a Useful Starting Material for the Soluble Polymer-Supported Synthesis of Imines and 1,2,3,4-Tetrahydroquinolines
✍ Rita Annunziata; Maurizio Benaglia; Mauro Cinquini; Franco Cozzi 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 279 KB 👁 2 views

A 4-alkylthio-substituted aniline anchored to a modified poly(ethylene glycol) of M w = 5000 was selected as a convenient starting material for the liquid-phase synthesis of various imines. Some of these imines were employed in a three-component synthesis of 1,2,3,4-tetrahydroquinolines, carried out

A facile approach to the synthesis of 3,
A facile approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives through the use of a ‘volatilizable’ support
✍ Yangmei Li; Marc Giulianotti; Richard A. Houghten 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 190 KB

A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a 'volatilizable' support. The products were cleaved with 10% HF and were obtained in high yields and purities.