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Synthesis of a library of 1,2,3,7-tetrasubstituted indolizines using poly(ethylene glycol) as soluble support

✍ Scribed by Guizhou Yue; Zuxing Chen; Guichun Yang

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
386 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

magnified image

A library of 1,2,3,7‐tetrasubstituted indolizines has been synthesized using poly(ethylene glycol) (PEG) as soluble polymer support. The PEG‐bound pyridinium salts reacted with alkenes or alkynes in the presence of Et~3~N via 1,3‐dipolar cycloaddition to give PEG‐bound indolizine derivatives, which were cleaved by 1 % KCN/MeOH to afford 1,2,3,7‐tetrasubstituted indolizines in good to excellent yields.

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