A Facile Synthesis of 5-Phenylimidazo- [4,5-c]-[1,8]naphthyridin-4(5H)-one
✍ Scribed by Kuge, Yukihiro; Kato, Nobuyuki; Sugaya, Toru; Tomioka, Shinji
- Book ID
- 111686975
- Publisher
- Taylor and Francis Group
- Year
- 1994
- Tongue
- English
- Weight
- 291 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0039-7911
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📜 SIMILAR VOLUMES
## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
## Abstract A number of the thieno[3,2‐__c__][1,8]‐naphthyridin‐4(5__H__)‐ones are chemoselectively synthesized from 4‐(4′‐aryloxybut‐2′‐ynylthio)‐1‐phenyl‐1,8‐naphthyridin‐2(1__H__)‐ones in 82–90% yield by the formation of sulfoxide, followed by [2,3] and [3,3]sigmatropic rearrangement and an intr