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A facile and novel synthesis of 5-phenylimidazo[4,5-c][1,8]naphthyridin-4(5H)-ones

✍ Scribed by Takeshi Kuroda; Fumio Suzuki

Book ID
112130216
Publisher
Journal of Heterocyclic Chemistry
Year
1991
Tongue
English
Weight
297 KB
Volume
28
Category
Article
ISSN
0022-152X

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## Abstract A number of the thieno[3,2‐__c__][1,8]‐naphthyridin‐4(5__H__)‐ones are chemoselectively synthesized from 4‐(4′‐aryloxybut‐2′‐ynylthio)‐1‐phenyl‐1,8‐naphthyridin‐2(1__H__)‐ones in 82–90% yield by the formation of sulfoxide, followed by [2,3] and [3,3]sigmatropic rearrangement and an intr