Overexpression of p21WAF1/CIP1 induces c
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Takashi Kokunai; Ichiro Izawa; Norihiko Tamaki
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Article
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1998
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John Wiley and Sons
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French
β 215 KB
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p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti