## Abstract The abnormal accumulation of methylglyoxal (MG), a physiological glucose metabolite, is strongly related to the development of diabetic complications by affecting the metabolism and functions of organs and tissues. These disturbances could modify the cell response to hormones and growth
Involvement of p21WAF1/Cip1, CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition
โ Scribed by Zauberman, Ayelet; Oren, Moshe; Zipori, Dov
- Book ID
- 110060935
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 349 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti
## Abstract Strong activation of the ERK signal is required for hepatocyte growth factor (HGF) to inhibit proliferation of the human hepatocellular carcinoma cell line HepG2. However, it is still to be elucidated whether the activation alone is sufficient to induce the inhibitory effect. In this st