𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A convergent approach to functionalised alkynes

✍ Scribed by Jean Boivin; Sylvain Huppé; Samir Z Zard

Book ID
104255812
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
209 KB
Volume
37
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile --hydride, cyanide, or phosphite--and exposure of the adduct to sodium nitrite / aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.

📜 SIMILAR VOLUMES

A New Convergent Approach to α-Branched
A New Convergent Approach to α-Branched Alkynes.
✍ Delphine Renard; Hadi Rezaei; Samir Z. Zard 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

ChemInform Abstract: A Convergent Approa
ChemInform Abstract: A Convergent Approach to Functionalized Alkynes.
✍ J. BOIVIN; S. HUPPE; S. Z. ZARD 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

The convergent approach to a broad variety of functionalized alkynes starts with a Knoevenagel-type condensation of 4-unsubstituted isoxazolines with ketones or aldehydes. The resulting adducts are subjected to Michael addition with various nucleophiles such as hydride, cyanide or phosphite. Exposur