A concise approach to functionalised, homochiral pyrrolidinones
β Scribed by Mark J Bamford; Mark Beard; David T Cherry; Mark G Moloney
- Book ID
- 103977074
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 247 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Knoevenagel type condensation of 4-unsubstituted isoxazolinones with ketones or aldehydes followed by Michael addition of a nucleophile --hydride, cyanide, or phosphite--and exposure of the adduct to sodium nitrite / aqueous acetic acid and ferrous sulfate gives variously functionalised alkynes.
A new substituted 5,6-dihydro-2(lH)-pyridinone participates in highly efficient Diels-Alder reactions to give functional&d cis-hydroisoquinolines suitable for natural product synthesis. The cis-hydroisoquinoline ring system constitutes an important part of natural products such as the indole alkalo