The solid-phase syntheses of enkephalin and somatostatin analogues with C-terminal OH functions instead of the normal carboxylates are described. The OH function of the N-terminal amino alcohol was acylated with succinic acid and esterified to the solid support. Normal Boc-TFA solid-phase strategy c
A convenient preparation of C-terminal peptide alcohols by solid phase synthesis
β Scribed by J Swistok; J.W Tilley; W Danho; R Wagner; K Mulkerins
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 246 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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This paper describes a novel solid phase peptide synthesis method for the systematic C-terminal modification of cysteine-containing peptides. In this method, cysteine is linked to chloromethylated polystyrene resin by its thiol functionality, followed by protection of the N-terminus and derivatizati
## Abstract Solidβphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for