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Convenient solid phase synthesis method for the preparation of cysteine C-terminally derivatized peptides

✍ Scribed by N. G. J. Delaet; T. Tsuchida

Publisher: Springer Netherlands
Year: 1996
Tongue: English
Weight: 513 KB
Volume: 2
Category: Article
ISSN: 1573-3149
DOI: 10.1007/bf00119995

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✦ Synopsis

This paper describes a novel solid phase peptide synthesis method for the systematic C-terminal modification of cysteine-containing peptides. In this method, cysteine is linked to chloromethylated polystyrene resin by its thiol functionality, followed by protection of the N-terminus and derivatization of the carboxylic acid to esters or amides. We report here on examples of the methodology and its application to the synthesis of Ac-Asp-cyclo(Cys-Gly-Pro-Cys)-NHBzl, a cyclic peptide amide. The method has been applied to the synthesis of complex esters as well as amides.

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