A convenient high yielding synthesis of nor-alcohols from carboxylic acids
โ Scribed by Barton, Derek H. R.; Bridon, Dominique; Zard, Samir Z.
- Book ID
- 119969961
- Publisher
- The Royal Society of Chemistry
- Year
- 1985
- Tongue
- English
- Weight
- 223 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-4936
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๐ SIMILAR VOLUMES
by basic hydrolysis is the standard method to prepare cyclopropene carboxylic acidst2). We have found, however, that if the cyclopropene resulting from the initial addition has a benzylic hydrogen adjacent to the ring, the alkaline hydrolysis condition lead instead to methylenecyclopropane acids. T
A convenient method for the formation of carboxamides from carboxylic acids and primary amines in the presence of molecular sieves is described. This process is very chemoselective.
Appropriate secondary amines are readily converted to nitroxides by dimethyldioxirane in a rapid, convenient, and essentially quantitative process. We earlier reported2 that dimethyldioxirane3, 1, oxidizes primary amines to nitro compounds in a facile, high yield process. While continuing our work