## Abstract For Abstract see ChemInform Abstract in Full Text.
A convenient synthesis of amides from carboxylic acids and primary amines
โ Scribed by J. Cossy; C. Pale-Grosdemange
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 232 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A convenient method for the formation of carboxamides from carboxylic acids and primary amines in the presence of molecular sieves is described. This process is very chemoselective.
๐ SIMILAR VOLUMES
Ab4tic.Z . 2-Trimethylsilylethanol was used to trap isocyanates produced by the Curtius rearrangement of acyl azides and the resulting trimethylsilylethyl carbamates were readily cleaved with tetra-n-butylammonium fluoride to liberate the primary amines.
A one-pot preparation of carboxylic acids is described that proceeds from their corresponding amides by a 'dry' hydrolysis with phthalic anhydride in the absence of water and solvent. The method affords carboxylic acids in good yields and is applicable to a variety of substrates.
T h e r e a c t i o n conditions for t h e p r e p a r a t i o n of a m i d e s f r o m l a b e l l e d c a r b o x y l i c a c i d s and a m i n e s u s i n g EEDQ (2-ethoxy-l(2H)-quinolinecarboxyl i c a c i d , e t h y l e s t e r ) a s a r e a g e n t w e r e m o d i f i e d f o r the s y n t h e
by basic hydrolysis is the standard method to prepare cyclopropene carboxylic acidst2). We have found, however, that if the cyclopropene resulting from the initial addition has a benzylic hydrogen adjacent to the ring, the alkaline hydrolysis condition lead instead to methylenecyclopropane acids. T