A control theoretic approach to malaria immunotherapy with state jumps

✍ Scribed by H. Chang; A. Astolfi; H. Shim

• Book ID: 104003230
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 588 KB
• Volume: 47
• Category: Article
• ISSN: 0005-1098
• DOI: 10.1016/j.automatica.2011.03.009

✦ Synopsis

We investigate a control method for malaria dynamics to boost the immune response using a model-based approach. The idea of state jump is introduced and discussed using a hybrid model. To implement the state jumps we use a physiologically feasible method for the biological system, whereby the introduction of a pathogen into the system steers it to a desirable status. It is noted that we take advantage of a pathogen to implement state jumps in the system. The study is supported by recently reported experimental results.