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A concise synthesis of (−)-neplanocin A

✍ Scribed by Naoyuki Yoshida; Takashi Kamikubo; Kunio Ogasawara


Book ID
108386811
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
115 KB
Volume
39
Category
Article
ISSN
0040-4039

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Total synthesis of (−)-neplanocin A
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Neplanocin A has been prepared in 14 steps from cyclopentadiene (11% overall yield). The recent attention directed at the synthesis of compounds for the treatment of viral infections has resulted in a large number of nucleoside analogues displaying antiviral activity. Neplanocin A (NPC-A) 1, a nat